Friday, September 23, 2016

Statins and Neurological disorders. Aleem M A. BMJ 2016;354:i4992

BMJ

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Statins: we need an independent review

BMJ 2016; 354 doi: http://dx.doi.org/10.1136/bmj.i4992 (Published 15 September 2016)

Cite this as: BMJ 2016;354:i4992

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Re: Statins: we need an independent review
 

Statins and Neurological disorders

At present Statins have the potential to provide a new therapeutic target for some neurological diseases. It is well established that statins reduce cholesterol levels and prevent cardiovascular disease. Statins can also have additional properties such as endothelial protection via action on the nitric oxide synthase system, as well as antioxidant, anti-inflammatory and anti-platelet effects.

These properties might have a potential therapeutic implication not only in stroke but also in neurological disorders such as Alzheimer disease, Parkinson's disease, multiple sclerosis and primary brain tumors. In addition to their potent anti-atherosclerotic and cardio-protective effects, compelling clinical and preclinical studies delineate the neuro-protective efficacy of statins in all these neurological disorders.

Neurological side effects

Statins can produce muscles pain and weakness. Some people with statins may have memory loss or confusion. These side effects reverse once you stop taking the statins.

Competing interests: No competing interests

22 September 2016

M A Aleem

Neurologist

ABC Hospital. Dhanalakshmi Srinivasan Medical college and hospital.Apollo hospital

Annamalainagar Trichy 620018.Dhanslakashmi Srinivasan medical college and Hospital Perambalure 621113. Apollo Hospitals Trichy 620010.Tamilnadu India

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